How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?
نویسندگان
چکیده
منابع مشابه
How well is enzyme function conserved as a function of pairwise sequence identity?
Enzyme function conservation has been used to derive the threshold of sequence identity necessary to transfer function from a protein of known function to an unknown protein. Using pairwise sequence comparison, several studies suggested that when the sequence identity is above 40%, enzyme function is well conserved. In contrast, Rost argued that because of database bias, the results from such s...
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15 صفحه اولEnzyme function less conserved than anticipated.
The level of sequence similarity that implies similarity in protein structure is well established. Recently, many groups proposed thresholds for similarity in sequence implying similarity in enzymatic function. All previous results suggest the strong conservation of enzymatic function above levels of 50% pairwise sequence identity. Here, I argue that all groups substantially overestimated the c...
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Within a single alignment of two DNA sequences or two protein sequences, some regions may be much better conserved than others. Such strong conservation may reveal a region that possesses an important function. When alignments are so long that it is infeasible, or at least undesirable, to inspect them in complete detail, it is helpful to have an automatic process that computes information about...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2003
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2003.08.057